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Nevertheless, a major concern arises from the direct injection of the mixture of IL-12 and aCTLA-4 (IL/aC), which may result in uncontrolled activation of immune cells and an IL-12-induced cytokine storm 23

References 1.Raja S.N., Carr D.B., Cohen M., Finnerup N.B., Flor H., Gibson S., Keefe F.J., Mogil J.S., Ringkamp M., Sluka K.A., et al

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13 Glutaminolysis is one of the most important hallmarks of metabolic reprogramming