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Additionally, according to another large trial in Germany, sham acupuncture and traditional Chinese acupuncture improve functionality and pain in OA patients of the knee even more than standard therapy, with no difference observed in the results of sham and traditional Chinese acupuncture [59]

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Therefore, more studies on the topic of the optimal dosing of Se, the optimal chemical form of the Se supplements, the optimal duration of Se supplementation, an optimal biomarker to follow, and its goal levels to achieve the optimal reproductive health effects in men need to be performed in the future