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Experimental inhibition of IGF-1induced signaling attenuates lipid synthesis and inflammation in human sebocytes, supporting diet and metabolism as modifiable exposomal drivers of acne ( 7.1.2 Retinoid signaling and endocrine modulation of sebocyte function Retinoids exert their biological effects through retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which function as ligand-activated transcription factors regulating sebocyte differentiation, lipid synthesis, and inflammatory responses (374)