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Behavioral factorsincluding changes in physical activity, sleep duration, and dietary intakealso co-vary with cycle phase and lipid concentrations, further complicating attribution to ovarian hormones alone [96,136,137]

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It took the brand manufacturers more than two years to build enough capacity for the FDA to declare the shortages over, which happened on December 19, 2024, for Eli Lillys tirzepatide products, and February 21, 2025, for Novo Nordisks semaglutide products

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