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602 The authors identified a new enzyme, TOT1, to be the responsible enzyme, using a combination of biotransformation, in vitro biochemical characterization, and computational modeling (Figure 74)

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Oxidative stress has been demonstrated to play a significant role in the mechanism of aging

Chem Biol Interact 224:164175 Lushchak VI, Bagnyukova TV (2007) Hypoxia induces oxidative stress in tissues of a goby fish, the rotan Percottus glenii