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Glutamine-deprived T-cells have also been shown to differentiate into FoxP3+ Tregs instead of Th1 helper cells, a defect that could be circumvented by simply feeding cells the cell-permeable -KG (33)

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

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These benefits are mediated through various mechanisms, including the reduction in oxidative stress, modulation of inflammation, and support for gutbrain axis interactions