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FIGURE 2 HSF1 serves as a sensor of various modalities that detect disturbances in homeostasis and activate HSP expression

Life 13(3):735 Karageili H et al (2023c) Comprehensive metabolite profiling of Berdav propolis using LC-MS/MS: determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects

Furthermore, in the course of the present invention it turned out that, if the biological sample comprises protein (typical biological samples such as cell samples or biopsy samples do, of course), it is beneficial to remove the protein from species to be measured by MS for increased accuracy and sample stability as well as reduced loss of (typically very expensive) heavy isotopologue of maleimide in the labelling reaction (which would be partially quenched by sulfhydryl groups present in protein)

Press gently into skin to help absorption 4

Protein G is coated onto hydrophilic beads