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[146] demonstrated that the regulation of circadian rhythms with melatonin treatment could maintain the anaboliccatabolic balance during OA development, providing a regulatory mechanism linking melatonin to the circadian rhythm and treatment for OA

long-term safety and efficacy in humans have not been fully established

[PUBMED Abstract] Pullen J, Boyett J, Shuster J, et al.: Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study

Food and function

10.1186/s13063-018-2600-0 9 DaenenK.AndriesA.MekahliD.Van SchepdaelA.JouretF.BammensB
