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10.1111/cns.13536 71 KaraaA.BertiniE.CarelliV.CohenB
Once inside the cell, the intracellular metal reductase STEAP3 reduces Fe3+ back to Fe2 +, which is then released into the cytosolic labile iron pool by the divalent metal transporter 1 [49]
Briefly, in neoadjuvant settings, preoperative EsCu@NPs reduce tumor burden, decrease minimal residual disease, curb postsurgical recurrence and spontaneous lung metastasis, translating into prolonged survival
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