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Additionally, histone ubiquitination, exemplified by H2Bub1, acts as a prerequisite for establishing H3K4me3 and H3K79me3 marks and further fine-tunes ferroptosis through the regulation of SLC7A11 and related gene expression (211)

On the other hand, Fe 2+ and Fe 3+ are also cofactors that can enhance the activities of various metabolic enzymes, resulting in the formation of free radicals such as alkoxy (RO) and peroxy (RO 2 ), promoting lipid peroxidation, and inducing ferroptosis ( 1 ) and iron regulatory protein 2 (IRP 2 ) regulate intracellular iron storage, release, entry, and exit, thereby maintaining cellular iron homeostasis

From day 3-5, I experienced severe fatigue which felt like a hayfever attack

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