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It supports the functionality of the mitochondria, intracellular organelles essential for energy production from the metabolism of dietary glucose, and protects their DNA

doi: 10.1055/a-0856-1044 15 ChaudharyS.DuttaD.KumarM.SahaS.MondalS

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This could explain the plasma membrane translocation of arrestin 3-GFP observed in the study of Navratilova and colleagues with the S363A DOR mutant (Navratilova et al., As demonstrated for MOR and DOR, KOR also undergoes an arrestin-dependent sequestration when activated by U50,488 as shown by the reduction of internalization when the dominant negative mutant arrestin 2 319418 is over-expressed (Li et al., Together, those data indicate that arrestins are key partners of OR internalization but under specific conditions or agonist exposure, other arrestin-independent mechanisms could occur