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Description
Second, proteostasis disruption involves declined autophagylysosomal and ubiquitinproteasome activity, rendering proteins like syn prone to aggregation and resistant to clearance [62]

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J Gastrointest Oncol (2018) 9:76977
In vitro experiments indicate that stimulating FOXO3 expression significantly decreases the generation of ferroptosis-related markers like MDA, suggesting its potential to suppress OA progression (Zhao et al., 2023)