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Additionally, while AOD-9604 demonstrated excellent safety in the studied populations, individual medical histories may reveal contraindications or concerns requiring careful evaluation

Unless the released fatty acids are actually oxidized which requires an energy demand the body is not otherwise meeting they are re-esterified and re-stored

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Chronic infections and biofilm are harder to treat

Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion