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2008;294:G1060G1069

4-Hydroxynonenal is involved in the signaling of cell proliferation and apoptosis, as well as regulating gene expression in different cell types (Cheng et al., 2001

GPX3 was identified as a potential target, with the highest expression level among the antioxidant enzymes examined in the rat Achilles tendon

It is distinct from other forms of regulated cell death in terms of morphology, biochemical features and gene expression (10)