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With the developments in material science over the years, various two-piece suppository molds have been produced using different metal combinations and are still in use today

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Cell 45, 1324 10.1016/j.molcel.2011.10.021 [DOI] [PMC free article] [PubMed] [Google Scholar] 28.Martin J.A., Sastre J., de la Asuncin J.G., Pallard F.V

For a more detailed history and the request for comments on the proposed rule, initially published on January 12, 1979, see 44 FR 2932 The 1979 FTC Staff report (PDF) titled Drug Product Selection contains a detailed history of antisubstitution laws, the transition to substitution laws, pricing, and estimated savings from adopting substitution laws

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