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A., Saeb-Parsy, K., Hamed, M
Nature 643 , 13811390 (2025)
Within dopaminergic neurons of the SNpc, these pathways promote oxidative stress, impair mitochondrial dysfunction, and promote apoptotic signaling [13]
The transcriptional activity of YAP through Hippo pathway is regulated by upstream kinases MST1/2 and large tumor suppressor kinases 1/2 (LATS1/2), then the phosphorylation of YAP Serine 127 (Ser127) by LATS1/2 leads to its retention in the cytoplasm and is targeted for proteasomal degradation 24
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