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This was evidenced by the downregulation of cytoplasmic mtDNA-related cGAS-STING and NLRP3 inflammasome signaling pathways, as well as reduced expression of proinflammatory factors IL6, IL1, and TNF- in Tibetan M9a+sh EPAS1 cells

10.1016/j.jacc.2014.09.028 Pubmed Abstract CrossRef Google Scholar View reference in article 28

Unquenched ROS molecules lead to the formation of protein carbonyls, advanced glycation end products, lipofuscins, start the process of lipid peroxidation and lead to pronounced DNA damage (especially 8-oxo-2'deoxyguanosine)

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I received my ADN in 1999 and my BSN in 2005