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Enrichment pathways of genes related to changes in MIND Based on three ontology sources, we used Metascape software to annotate the functions of the PLS2 +/ genes and identify statistically significant biological processes

Regarding anti-inflammatory therapy, COX-2 inhibitors (e.g., rofecoxib, celecoxib) have demonstrated potential benefits in reducing symptom scores in randomized trials, and inflammatory markers in prostatic fluid or seminal plasma (e.g., IL-8) can serve as objective supplements for efficacy monitoring (60, 204, 205)

Fan Y, Zhang Y, Peng C, Chang X, Sun L, Kong XJ, Zhang BZ, Dong LY, Wang XH

Moreover, peptides are sensitive to chemical and physical instability, increasing the risk of degradation during development and storage

Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D