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Experimental studies further show that these fibrils are structurally stable and highly neurotoxic, their introduction into the colon reproduced key motor and cognitive deficits associated with PD [134, 135], underscoring the role of secretase as a molecular link between peripheral inflammation and central neuropathology
10.3760/cma.j.issn.1673-4246.2018.05.009 30 HeW.ShuX.ZongG.ShiM.XiongY.ChenM
TGM2 is also remarkably specific for the glutamine residues that provide the substrate for the first step in the cross-linking reaction
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