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For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks

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These bacteria are widely distributed in environmental reservoirs such as soil, water, and organic matter and can colonize the human gastrointestinal tract

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