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2021;53:e13666

Molecular mechanisms of G protein-coupled receptor desensitization and resensitization

Nicotine acetylcholine receptors (nACHRs) (Ni et al., 2013) and using an antagonist of 7nAChR can actually inhibit the proliferation of microglia and reduce the expression of inflammatory factors IL-1 and TNF- (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)

Most patients will develop no or mild symptoms, while some patients may develop hyper-inflammation caused by the production of a large amount of cytokines, known as a cytokine storm, which may lead to fatal pneumonia and acute respiratory distress syndrome (ARDS)