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However, eribulin directly acts on angiogenesis-associated pathways, including VEGF ( Vegfa , Vegfr1 , Vegfr2 , and Vegfr3 ), Notch ( Dll4 , Jag1 , and Notch4 ), Eph ( Efnb2 , Epha2 , and EphB1 ), and WNT ( Wnt5a , Wnt11 , and BPM4 ), thus resulting in vascular remodeling

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His test case is his former assistant, 28-year-old Kate Tolo, who told Time that she used to work in fashion and took a pay cut to work for Johnson

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