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multiple organ lesions, i.e., the heart dilatation, myocardial congestion and confluent areas of subendocardial ischemic myocytes, ECG disturbances (i.e., giant T-wave)

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Desensitization of endogenously expressed delta-opioid receptors: no evidence for involvement of G protein-coupled receptor kinase 2

They are not recognized as generally regarded as safe (GRAS) substances for dietary supplement use