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Over time, these low levels can cause toxins to build up in the body

Acknowledgements This work was supported by grants from the Qatar Biomedical Research Institute (Project Number SF 2019 004 and IGP5-2022-001 to Y.P.) and the HBKU Thematic Research Grant (Project Number VPR-TG02-06 to Y.P.)

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This model is supported by evidence from various experimental systems, including the ability of lactate to sustain synaptic function in vitro (Schurr et al., 1988), the cellular localization of relevant transporters and enzymes, and in vivo studies using microsensors that report rapid lactate consumption coupled to oxygen utilization in the tissue parenchyma during activation (Hu and Wilson, 1997)

Although the lack of FASN affected several other metabolic pathways associated with transformation 31 (Fig