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Vivo (Athens, Greece) 29 (3), 405408
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301,305,306,307 MKP-1 is an archetypal member of the dual specificity phosphatase family that inactivates the MAPK activity in response to pro-inflammatory stimuli
& Ohdan, H
In proteins, specific hydrogen-bond donors and an electropositive local environment tend to lower the pK a by stabilizing the thiolate, and a hydrophobic environment or an electronegative local environment tends to raise the pK a by destabilizing a negatively-charged as opposed to neutral form of the side chain (for a few specific examples of these effects, see [14, 3032])
