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Clinically, in patients with renal failure, acute kidney injury, dialysis and other pathological states of renal function deterioration, renal reabsorption function is impaired, resulting in a significantly lower serum free carnitine concentration than that in healthy people [255], and the metabolic profile of acylcarnitine also changes significantly [256]

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12 Brain imaging studies have shown central sensitization in fibromyalgia patients is associated with alterations in brain structure, neurotransmitter function, and patterns of brain activity at rest and when exposed to experimental pain

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doi: 10.1089/dna.2013.2132 292 YaoQ.ChenY