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The conversion of glucose to fructose involves the polyol pathway where glucose is first reduced to sorbitol via the action of the aldose reductase encoded by the AKR1B1 (aldo-keto reductase family 1 member B) gene

The tissue of the two brain regions was homogenized (10% w/v) in an ice-cold buffer containing 1.15% KCl and 0.01 M sodium phosphate buffer (pH 7.4) per gram tissue

Another transcription factor that specifically responds to HOCl is NemR, which is activated via oxidation of HOCl-sensitive cysteine residues