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Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function

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Poster session II - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.06 - CARDIOEMBOLISM & HEART-BRAIN INTERACTIONS P961 - ESOC25-1084 ATRIAL FIBRILLATION (AF) DETECTED BY IMPLANTABLE CARDIAC MONITOR IN PATIENTS WITH NON-STROKE INDICATIONS IMPLICATIONS FOR DEVICE-DETECTED AF AFTER STROKE Cortney de la Torre 1 , Devon Shafer 1 , Jindong Xu 1 1 Cone Health, Greensboro, United States Background and Aims: The use of implantable cardiac monitors (ICMs) has greatly increased the detection of AF in cryptogenic stroke patients

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