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Keywords: nondiabetics, obesity, overweight, tirzepatide Abbreviations AHI apneahypopnea index BMI body mass index CI confidence interval DM diabetes mellitus FDA Food and Drug Administration GI gastrointestinal GIP glucosedependent insulinotropic polypeptide GLP1 glucagonlike peptide1 GLP1 RA glucagonlike peptide1 receptor agonist HbA1C glycated hemoglobin HDL highdensity lipoprotein LDL lowdensity lipoprotein MD mean difference MTD maximum tolerated dose OR odds ratio OSA obstructive sleep apnea PAP positive airway pressure PRISMA Preferred Reporting Items for Systematic Reviews and MetaAnalyses RCT randomized controlled trial RoB 2 version 2 of the Cochrane riskofbias tool for randomized trials RR relative risk VLDL verylowdensity lipoprotein 1

The management of B12 deficiency is straightforward

Reverse transcription was performed using the High Capacity cDNA Reverse Transcription Kit (Applied Biosystems, Thermo Fisher Scientific, Waltham, MA, USA) following manufacturers instructions and using a ProFlex PCR System machine (Applied Biosystems, Thermo Fisher Scientific, Waltham, MA, USA)

Then they go to see you

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