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In contrast, cells in the lens nucleus have lost their capacity to synthesise GSH [49], and rely on anaerobic metabolism to produce their energy requirements [50]

doi: 10.1038/s41593-020-00793-2

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While ACSL4 has been shown to be significantly upregulated and GPX4 to be downregulated in colonic biopsies of patients with CD, other ferroptosis biomarkers, such as MDA, prostaglandin-endoperoxide synthase 2 (PTGS2) and FTH1 are upregulated and GPX4 is downregulated in the colon of the animal model