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Wang Y, Yao M, Wang J, et al
doi: 10.1038/s41574-021-00550-w 63 MiermeisterCPPetersennSBuchfelderMFahlbuschRLdeckeDKHlskenAet al
A dysfunctional ROS-scavenging system leads to excessive ROS accumulation in cells and lipid peroxidation, mainly in the cell membrane resulting in a loss of membrane properties and ferroptosis
The expression of several GSTFs including GSTF7 and a GSTL gene were also markedly up-regulated after the fungal inoculation (Figure 2A)
To prevent further splicing of the pLEX-3HA-XBP1u transcript by IRE1 which reduces XBP1u protein expression, both splicing sites were mutated (1st: AG TC CG^CA to AG AG CGCA
