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Notably, the transfer through the placenta can serve as a valuable factor for describing distribution within the human placenta

Pemmaraju N, Carter BZ, Bose P, Jain N, Kadia TM, Garcia-Manero G, Bueso-Ramos CE, DiNardo CD, Bledsoe S, Daver NG, Popat U, Konopleva MY, Zhou L, Pierce S, Estrov ZE, Borthakur GM, Ohanian M, Qiao W, Masarova L, Wang X, Mak PY, Cortes J, Jabbour E, Verstovsek S

found that citrate-covered gold nanoparticles (Cit-AuNP) could prevent the process of NF-B translocation to the nucleus by decreasing the phosphorylation of inhibitor of kappa B alpha (IB), which was followed by decreased expression of pro-inflammatory factor ICAM-1 on leukocytes and reduced adhesion of leukocyte to the endothelium of intracerebral blood vessels, ultimately alleviating the inflammatory response in the brain by BBB protection and reducing the occurrence of SAE during sepsis (Di Bella et al., 2021) ( Figure 2 )