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MRI revealed symmetrical white matter lesions in the corticospinal tract (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury ( Heroin also induces psychiatric symptoms, such as depression, anxiety, impulsiveness, and interpersonal sensitivity (Pasternak, 2012)

Zhu Y, Zhang G, Zhao J, Li D, Yan X, Liu J, Liu X, Zhao H, Xia J, Zhang X, Li Z, Zhang B, Guo Z, Feng L, Zhang Z, Qu F, Zhao, G (2013)

Choline contributes to normal lipid metabolism

Barton, the discussant, praised the trials rigorous methodology and proposed that there may have been several reasons for the lack of ALC benefit in preventing neuropathy, despite compelling earlier data

In addition, tranexamic acid reduced mortality of bleeding by about one third