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Visual changes often precede scale changes, especially when fat loss is accompanied by lean mass preservation

Journal of Ethnopharmacology 26811356910.1016/j.jep.2020.113569 141 ZhaoX.XueX.WangC.WangJ.PengC.LiY

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were the first to encounter CHAC1 expression in the context of cancer cell death ( CHAC1 gene is highly upregulated in HNSC cancer after treatment with nisin which was then followed by cell death ( CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues ( CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed ( CHAC1 is upregulated by the ATF4-CHOP cascade and leads to cell death by perturbation of the redox homeostasis through changes in the ROS levels (Wang et al., 2022)