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Metabolism of 2024 FDA approved small molecules part 1 By Julia Shanu-Wilson Involvement of active metabolites The number of small molecules approved by the FDA in 2024 totaled 31 out of 50 NMEs with 56% (28) of these comprising small molecule therapies

Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury (101)

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[DOI] [Google Scholar] 222.Hazen T.E
