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If those mutations occur in a gene important to cancer prevention, then a tumor can occur.[ref] Thus, folate helps to prevent the mutations that cause cancer, yet in someone who has cancer, folate and methyl groups can fuel cancer cell growth

doi: 10.1038/s41420-022-01212-0 177 JalilADonateMMMatteiJ

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These agents inhibit di- and tetrahydrofolate reductase activity in humans resulting in a disruption of one carbon metabolism 60,61

Pepsin is a vital digestive enzyme that catalyzes the breakdown of proteins into smaller peptides, facilitating their absorption in the intestine 53