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When exercise inhibits the Akt/mTORC1 - SREBP-1 pathway, it can reduce the expression and activity of SREBP-1, thereby diminishing the transcriptional activation of lipogenic genes like ACC and FAS, leading to decreased hepatic lipid synthesis and accumulation [49]
Transfection of siRNAs and senolytic screen Druggable genome siRNA libraries were purchased from Horizon Discovery (human siGENOME SMARTpool)
