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5 children (15.1%) had intolerable side effects and were withdrawn

Given that glutamate is the major excitatory neurotransmitter in the central nervous system and NMDARs play critical roles in synaptic activity, it is not surprising that maladaptive NMDAR signaling is implicated in a broad range of neuropsychiatric, neurodevelopmental, and neurodegenerative disorders [6]

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Research in stem cells has suggested an upregulation of markers associated with neuronal differentiation, which could point toward possible roles in epigenetic regulation

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