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Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study

Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases

Without Phase II, every Phase I metabolite would accumulate as a free radical, causing more damage than the original toxin

Nature (2016) 540:58387.10.1038/nature20597 137 SesterDPSagulenkoVThygesenSJCridlandJALoiYSCridlandSOet alDeficient NLRP3 and AIM2 inflammasome function in autoimmune NZB mice
