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This conclusion is robust to adjustments for the active content and the actual dose administered

Nat Rev Dis Primers (2016) 2:16003

Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis

CHIMERA model has also been more recently applied to gyrencephalic ferrets, also reporting axonal injury based on enhanced APP signal, and neurofilament M (RMO) levels, as well as increase in tau phosphorylation AT180 at the base of the sulci by using a higher intensity impact, in turn offering a possible CTE animal simulation (Krieg et al., 2023)

The cells were washed with PBS twice before staining with X-gal solution [1 mg/mL 5-bromo-4-chloro-3inolyl--D-galactoside (Boehringer Manneheim #745-740) in N,N-dimethylformamide, 5 mM potassium ferricyanide crystalline (#P-8131), 5 mM potassium ferricyanide trihydrate (#P-3289), 2 mM magnesium chloride, and 1x PBS, pH 6.0