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Adequate hydration, moderate fat intake (very low-fat diets paradoxically increase gallstone risk by reducing gallbladder contractility), and ursodiol prophylaxis for patients with known gallbladder disease risk factors may reduce this concern

[DOI] [Google Scholar] 47.Tanner E.E.L., Curreri A.M., Balkaran J.P.R., Selig-Wober N.C., Yang A.B., Kendig C., Fluhr M.P., Kim N., Mitragotri S

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Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes