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Description
The annulus fibrosus, having significantly weaker compression resistance than tensile resistance, gradually develops structural damage under continuous high pressure, manifesting as overall bulging beyond the endplate boundaries (visible as disc bulging on imaging)

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Li L, Wang H, Zhang J, Sha Y, Wu F, Wen S, He L, Sheng L, You Q, Shi M, Liu L, Zhou H.SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
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China J

Molinari et al., 2010