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PMID: 33620803

Although rapalog therapy causes tumor reduction in lymphangioleiomyomatosis (LAM) and angiomyolipoma (AML), each due predominantly to inactivating TSC2 mutations, there was a dramatic tumor regrowth after treatment cessation (15)

According to structural information for the catalytic domain of PDP1, it has been proposed that removal of Leu-213 disrupts the position of Asp-220 [111, 113]

MBs oscillate steadily in a specific region, generating shear and circumferential stresses on the microvascular wall of the BBB, which can open the BBB transiently

Acknowledgements The authors thank Simone Gasper and Juliane Rdiger for expert technical assistance