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Studies have shown that phase separation is involved in many important cellular processes such as RNA metabolism, signal transduction, and stress granule assembly
In glioblastoma, ferroptosis presents a unique vulnerability, as tumor cells exhibit ferroaddiction, an increased dependence on iron (Fe 2+ ) for metabolic functions, yet simultaneously deploy protective mechanisms to evade ferroptotic cell death (Fig

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It is found in most body cells, with the highest concentration in the liver

It has been shown that NO is also a potent inhibitor of NADPH oxidase production, which consequently reduces the formation of superoxide ions [52, 53]
