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Unlike TCZ, anakinra does not inhibit CRP synthesis directly

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Sakaguchi M, Kashiwabara H

reported that Shaoyao-Gancao Decoction (SGD), commonly used to treat multiple gynecological disorders such as dysmenorrhea, adenomyosis, and PCOS, modulated gut microbiota composition, and alleviated chronic low-grade inflammation by downregulating cytokines including IL-18, IL-1, IL-6, and TNF- in both serum and ovarian mRNA expression in PCOS rats (238)

Prescription peptides used under medical supervision have generally favorable safety profiles in published research, though risks vary by peptide, dose, and your individual health context