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However, their predominant reliance on singlereceptor mechanisms may overlook critical synergistic interactions among multiple barrier systems

doi: 10.1038/s41418-021-00814-y 61

Thus, in human endothelial cells, we found that adhesion molecules, such as vascular adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1), are upregulated by the absence of GPx1 and the expression of adhesion molecules is further augmented with exposure to TNF or lipopolysaccharide

This autocatalytic reaction occurs in a free radical chain that generates lipid hydroperoxides in the presence of iron [3]

This study indicated that the expression of glutamate transporters in astrocytes and microglia are differentially regulated following nerve injury