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To achieve clinical translation, sufficient preclinical experiments must identify effective therapeutic agents and the exact molecular mechanisms

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Researchers must also generate non-clinical evidence demonstrating that the compound interacts with the intended target and produces the expected pharmacological effects without showing major safety concerns

Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: In vivo functional test for the activity of glutamic acid decarboxylase

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Salehi B., Venditti A., Sharifi-Rad M., Krgiel D., Sharifi-Rad J., Durazzo A., Lucarini M., Santini A., Souto E.B., Novellino E., et al