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Overexpression of SIRT4 results in incomplete meiosis, insufficient mitochondrial redistribution, decreased ATP levels, increased ROS levels, severe spindle/chromosome disorganization, and partial rescue of age-related defects in oocytes through SIRT4 knockout [165, 173]

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Electronic supplementary material (PDF 1239 kb) Rights and permissions About this article Cite this article Gao, J., Cahill, C.M., Huang, X