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Other noteworthy phase 3 trial readouts in 2025 include: Novo Nordisks evoke/evoke+ , investigating oral semaglutide in patients with early Alzheimers disease, potentially expanding the utility of GLP-1s beyond cardiometabolic indications

Astrocyte transforming growth factor beta 1 protects synapses against a oligomers in alzheimer's disease model

doi: 10.1016/j.ejmech.2015.04.040 18 SharafADe MicheleRSharmaAFakhariSObornikM

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Real-time polymerase chain reaction (PCR) was performed with Takyon Rox SYBR master mix (Eurogentec, Seraing, Belgium) in a StepOnePlus (Applied Biosystems, Life Technologies, Foster City, CA, USA) using the following primers: IL-6 F 5ACTGGCAGAAAATAAGCTGAATCTTC 3 and R 5TGATCAAGCAAATCGCCTGAT3