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Systemic metabolic alterations and their relationship to neuropsychiatric symptomatology PAIS, including long COVID, as well as CFS and IMD, share the characteristic of systemic metabolic disturbances, which may be a sign of underlying multi-organ inflammation and exhaustion [31], and consequently may contribute to neuropsychiatric symptomatology, as many metabolites can cross the bloodbrain barrier (BBB) [30, 58] (e.g., short chain fatty acids (SCFAs) derived from the gut microbiota such as acetate [40], amino acids such as tryptophan [52] and also carnitine/acetylcarnitine can cross the BBB via transporters [59])

BMI stands for Body Mass Index

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10.1016/S0140-6736(22)01534-3 Summary Keywords mitral valve prolapse, mitral regurgitation, molecular biology, fibroelastic deficiency, Barlow disease, Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome Citation Ronco D, Buttiglione G, Garatti A and Parolari A (2023) Biology of mitral valve prolapse: from general mechanisms to advanced molecular patternsa narrative review

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